Chemical Engineering Fundamentals
In Biological Systems

Multimedia Educational Laboratory
Chemical Engineering Department
University of Michigan

Dr. Susan Montgomery, Director
http://www.engin.umich.edu/labs/mel
(734) 936-1890 smontgom@engin.umich.edu

Developed with funds from the
National Science Foundation
Grant EEC-9420567
 
 
 
 

Version 2.0 now available from:

CACHE Corporation
P.O. Box 7939
Austin, TX 78713

cache@uts.cc.utexas.edu, (512) 471-4933






The following multimedia-based educational materials, focusing on applications of chemical engineering concepts in biological systems, have been developed for both Macintosh and Windows platforms:
 


COURSE
Material Balances
Mass Transfer
Separations
Kinetics
Kinetics
TITLE
Material Balances
Oxygen Transport
Adsorption
Receptors
Bioremediation
ASSOCIATED FACULTY
Prof. Henry Y. Wang
Prof. David Mooney
Profs. Mark Burns and Henry Y. Wang
Profs. Jennifer Linderman and David Mooney
Prof. H. Scott Fogler

These modules provide interactive reviews of chemical engineering fundamentals. Real world examples increase studentsí interest in the material and provide real world applications of these fundamentals. Many of the modules also include simulations that allow students to explore the role of process parameters.
 


MATERIAL BALANCES


With Henry Y. Wang

This module helps students in the introductory chemical engineering course understand and practice the application of material balances to biological systems of different dimensions using an algorithm for the solution of material balance problems. In-depth interactions focus on mass balance problems involving cell metabolism, an artificial kidney, and a cheese factory.

Review of mass balance algorithm
Beginning steps, cheese plant mass balance


OXYGEN TRANSPORT


With David Mooney

This module focuses on the convection and diffusion of oxygen through the body . The Introduction consists of a review of convection and diffusion, and their effects on oxygen transport. The Quantitative Analysis section presents the relevant equations of convection and diffusion and presents the Krogh cylinder model, which illustrates how convection and diffusion compete in oxygen transfer through veins. This edition will include two case studies.

Introduction to convection and diffusion
Simplification of the mass transfer equation


ADSORPTION


With Mark A. Burns and Henry Y. Wang

This module focuses on applications of adsorption. The Introduction section explains the concept of adsorption, including an animation of the adsorption process. The Modeling and Equations section displays a mathematical model of adsorption. A simulator allows the user to select values for adsorbent diameter, length of column, inlet flow rate, maximum concentration of solute on adsorbent, and the adsorption constant, and learn the relative effects on column performance. A case study explores how protein A binds to the Fc portion of immunoglobulins and is isolated from other proteins

 

Adsorption column balance equations
Affinity adsorption case study


RECEPTORS


With Jennifer J. Linderman and David Mooney

This module reinforces concepts of kinetics in the context of receptor-ligand binding. The Introduction focuses on receptor-ligand binding and corresponding analysis techniques. The Interaction/Kinetics section focuses on the quantitative kinetics of simple receptor-ligand binding. A simulator allows the user to explore the effect of ligand concentration, reaction rate constants, total receptors and initial complexes on receptor-ligand binding. An allergy case study explores the role of signal transduction in allergic responses. A tissue engineering case study focuses on the seeding of cells on an artificial matrix.

Kinetics of receptor-ligand binding
Tissue engineering case study


KINETICS AND BIOREMEDIATION


With H. Scott Fogler

This module focuses on applications of kinetics to bioremediation and bacteria profile modification. It begins with an introduction to biological reactions, cells, types of reactors, and products. A quantitative approach to characterize kinetics and reactors is reviewed for both batch and continuous reactors. The Bacterial Profile Modification section introduces the user to applications of BPM to oil recovery. The user can use a simulation of the growth of cells in a batch reactor to explore the effects of cell and sugar concentrations and various kinetic parameters on cell growth. Requirements for successful bioremediation and different bioremediation techniques such as biostimulation and bioaugmentation are also explored.

Bio-Kinetics main menu
Continuous reactors in series

Return to Biological Systems page.