Sangyeul Hwang
Post-Doctoral Research Fellow
Education
- Ph.D. Chemistry (Materials), University of Michigan, 2002 – 2007
- M.S. Chemistry (Organic), Pohang University of Science & Technology (POSTECH), 1991 – 1993
- B.S. Chemistry, Soongsil University, 1986 – 1991
Experience
- Research Scientist (Part-time), Michigan Critical Care Consultants (MC3), Fall 2006
- Development of Novel Biocompatible Polymeric Materials, January 2003 – November 2007.
- New Polymeric Cationic Electrolyte of Fuel Cells, September 2002 – April 2003
- Senior Scientist (Full-time), LG life sciences R&D Research Park (LG Chem. Ltd.), 1993 – 2002
- New Drug Development (Antivirus & Antibiotic; Anti-Hepatitis B Virus (HBV), HIV Protease Inhibitor, Anti-Methicillin-Resistant Staphylococcus Aureus (MRSA), Oral Cephalosporin, Quinolone (approved by the FDA, 2003), January 1997 - July 2002
- Pilot & Plant Production by GMP Regulations, January 1997 - July 2002
- New Drug Discovery (Cardiovascular; Thrombin Inhibitor (LB30057 was contracted for sale to Park-Davis, now part of Pfizer, 1997)], January 1993 - December 1996
- Synthetic Utility of Chiral Molecules Obtained from Lipase AK-Catalyzed Hydrolysis, March 1991 - February 1993
Awards
- New Drug Discovery & Development Award, LG Chem. Ltd., April 2001.
- Valedictorian Graduation Award in the College of Natural Sciences, Soongsil University, February 1991.
- Full Scholarships, Soongsil University, March 1986 – February 1990.
Research
- Preparation of Multicompartmentalized Particles/Fibers Using Electrohydrodynamic Co-Jetting, Dec 2008 - Present
Publications
- K. J. Lee, Hwang, S., J. Yoon, S. Bhaskar, T.-H. Park, J. Lahann, "Compartmentalized photoreactions within compositionally aniostropic Janus microstructures", Macromolecular Rapid Communications, 2011 (online publication).
- Hwang, S., K.-H. Roh, D. W. Lim, G. Wang, C. Uher and J. Lahann, "Anisotropic hybrid particles based on electrohydrodynamic co-jetting of nanoparticle suspensions", Phys. Chem. Chem. Phys. 2010, 12, 11894-11899.
- Lim, D. W.; Hwang, S.; Uzun, O.; Stellacci, F.; Lahann, J. "Compartmentalization of Gold Nanocrystals in Polymer Microparticles using Electrohydrodynamic Co-Jetting" Macromol. Rapid. Commun. 2010, 31, 176-182.
- Hwang, S.; Meyerhoff, M. E. "Polyurethane with Tethered Copper(II)-Cyclen Complex: Preparation, Characterization and Catalytic Generation of Nitric Oxide from S-Nitrosothiols" Biomaterials, 2008, 29, 2443-2452.
- Hwang, S.; Cha, W.; Meyerhoff, M. E. "Amperometric Nitrosothiol Sensor Using Immobilized Organoditelluride Species as Selective Catalyst" Electroanalysis, 2008, 20, 270-279.
- Hwang, S.; Meyerhoff, M. E. "Organoditelluride-Tethered Polymers that Spontaneously Generate Nitric Oxide when in Contact with Fresh Blood" J. Mater. Chem. 2008. 18, 1784-1791.
- Hwang, S.; Meyerhoff, M. E. “Organoditelluride-Mediated Catalytic S-Nitrosothiol Decomposition” J. Mater. Chem. 2007. 17. 1462-1465.
- Hwang, S.; Cha, W.; Meyerhoff, M. E. “Polymethacrylates with Covalently Linked Copper(II)-Cyclen Complex for In Situ Generation of Nitric Oxide from Nitrosothiols in Blood” Angew. Chem. Int. Ed. 2006, 45, 2745-2748.
- Kim, B. C.; Hwang, S.; Lee, T. H.; Chang, J. H.; Choi, H.-w.; Lee, K. W.; Choi, B. S.; Kim, Y. K.; Lee, J. H.; Kim, W. S.; Oh, Y. S.; Lee, H. B.; Kim, K. Y.; Shin, H., “Development of a Scalable Synthetic Route towards a Thrombin Inhibitor, LB30057” Organic Process Research & Development 2006, 10, 881-886.
- Lee, K. W.; Hwang, S.; Kim, C. R.; Nam, D. H.; Chang, J. H.; Choi, S. C.; Choi, B. S.; Choi, H.-w.; Lee, K. K.; So, B.; Cho, S. W.; Shin, H., “The Chemical Development of LB71350” Organic Process Research & Development 2003, 7, 839-845.
- Lee. K.; Hwang, S.; Park. C. W., “Thrombin Inhibitors Based on a Propargylglycine Template”, Bioorg. Med. Chem. Lett., 1999, 7, 1013-1018.
- Lee, K.; Jung, W.-H.; Hwang, S.; Lee, S.-H., “Fluorobenzamidrazone thrombin inhibitors: influence of fluorine on enhancing oral absorption” Bioorg. Med. Chem. Lett., 1999, 9, 2483-2486.
- Oh, Y. S.; Yun, M. K.: Hwang, S.; Hong, S. W.; Shin, Y. S.; Lee, K.; Yoon, K. H.; Yoo, Y. J.; Kim, D. S.; Lee, S. H.; Lee, Y. H.; Park, H. D.; Lee, C. H.; Lee, S. K.; Kim. S. S., “Discovery of LB30057, a Benzamidrazone-Based Selective Oral Thrombin Inhibitor”, Bioorg. Med. Chem. Lett., 1998, 8, 631-634.
- Lee, K.; Hwang, S.; Hong, S. W.; Hong, C. H.; Lee, C. S.; Shin, Y. S.; Kim, S. S.; Yun, M. K.; Yoo, Y. J.; Kang, M. K.; Oh, Y. S., “Structural Modification of an Orally Active Thrombin Inhibitor, LB30057: Replacement of the D-Pocket-Binding Naphthyl Moiety”, Bioorg. Med. Chem. Lett., 1998, 6, 869-876.
- Lee, K.; Hwang, S.; Yun M. K.; Kim. D. S., “Potent and Efficacious Thienylamidine-Incorporated Thrombin Inhibitors”, Bioorg. Med. Chem. Lett., 1998, 8, 1683-1686.
- Lee, K.; Hwang, S., “Phosphamidate Derivatives of 4-Amidrazonophenylalanine: A New Class of Selective Thrombin Inhibitors”, Kor. J. Med. Chem., 1997, 7, 86-89.
- Kim, S. S.; Hwang, S.; Kim, Y. K.; Yun, M. K.; Oh, Y. S., “Rational Design of Selective Thrombin Inhibitors”, Bioorg. Med. Chem. Lett., 1997, 7, 769-774.
- Kim, M. J.; Lim, I. T.; Choi, G. B.; Hwang, S.; Ku, B. C.; Choi, J. Y., “The Efficient Resolution of Protected Diols and Hydroxy Aldehydes by Lipases: Steric Auxiliary Approach and Synthetic Applications”, Bioorg. Med. Chem. Lett., 1996, 6, 71-76.