Macromolecular Science
and Engineering Center

  • Shuichi Takayama
  • Department of Biomedical Engineering
  • Macromolecular Science & Engineering Center
  • 2115 Carl Gerstacker Bldg, 2200 Bonisteel
  • Ann Arbor, MI 48109-2099

Short Biosketch

Shuichi Takayama received his M.S. from the University of Tokyo in 1994 and his Ph.D. degree in chemistry from the Scripps Research Institute in 1998, after which he did postdoctoral studies at Harvard University as a Leukemia and Lymphoma Society postdoctoral fellow. He joined the faculty of the department of Biomedical Engineering at the University of Michigan, Ann Arbor, in the fall of 2000. His major research interests are in biomaterials, nanotechnology, microfluidics, and application of these technologies for cell-based therapies and biological studies.

Awards/Honors

Current Research

Research in Takayama group has been supported by NIH, NSF, Army, State of Michigan, Coulter Foundation, Wilson Foundation, USDA, Whitaker Foundation, NASA, Leukemia and Lymphoma Society, ORAU.

Microfluidics

We perform basic technology development in microfabrication methods, surface chemistry, electrowetting, multi-phase flow systems, valves, pumps, mixers, software development, integrated system development. We have a particular interest in development of polymer microfluidic systems for cell biology applications (Embryonic and Adult Stem Cells, Neurons, Hepatocytes, and other cell types noted below).

Nanotechnology

We have developed a rapid, inexpensive and biocompatible method for nanopatterning and nanofabrication based on cracking of polymer supported brittle thin films. Applications include switchable nanopatterned surfaces for modulation of cell spreading and migration. Tunable nanofluidic channels for single molecule and nanoparticle manipulations.

In Vitro Fertilization on a Chip

We have developed integrated microfluidic systems to improve handling of sperm, eggs, and embryos in the in vitro fertilization process. Specific devices we have developed include microfluidic sperm sorters, microfluidic inseminators, and microfluidic embryo culture systems. The devices produce better embryos, reduces cellular stress, and enhances pregnancy rates.

Cardiovascular Systems and Cancer Metastasis on a Chip:

We develop various microfluidic devices that incorporate endothelial cells and cancer cells to study cancer metastasis on a chip.

Lung On a Chip

We perform microfluidic tissue engineering of the small airway to study effect of fluid mechanical stresses generated in the lung under normal and pathologic conditions. Or more simply, we study why doctors listen to your lung with a stethoscope and what different sounds may mean to your lung at the cellular level.

Bone On a Chip

We perform microfluidic tissue engineering of the bone and bone marrow to study osteoblasts and hematopoietic stem cells.

Stem Cells On a Chip

We study microenvironmental effects on stem cell self-renewal and differentiation.

Cell Signaling

We develop novel microtools to study spatio-temporal effects on cell signaling.

List of Recent and Top Cited Publications

  1. Cho, B.; Schuster, T.G.; Zhu, X.; Chang, D.; Smith, G.D.; Takayama, S., "A Passively-Driven Integrated Microfluidic System for Separation of Motile Sperm" Anal. Chem. 75, 1671-1675 (2003)
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  2. Huh, D.; Tkaczyk, A. H.; Bahng, J.-H.; Chang, Y.; Wei, H.-H.; Grotberg, J. B.; Kim, C.-J.; Kurabayashi, K.; Takayama, S., "Reversible Switching of High-Speed Air-Liquid Two-Phase Flows Using Electrowetting-Assisted Flow-Pattern Change" J. Am. Chem. Soc. 125, 14678-14679 (2003)
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  3. Futai, N.; Gu, W.; Takayama, S., "Rapid Prototyping of Microstructures with Bell-Shaped Cross-Sections and Its Application to Deformation-Based Microfluidic Valves" Adv. Mater. 16, 1320-1323 (2004)
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  4. Gu, W.; Zhu, X.; Futai, N.; Cho, B. S.; Takayama, S., "Computerized Microfluidic Cell Culture Using Elastomeric Channels and Braille Displays" Proc. Natl. Acad. Sci. U.S.A. 101, 15861-15866 2004
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  5. Zhu, X.; Mills, K. L.; Peters, P. R.; Bahng, J. H.; Liu, E. H.; Shim, J.; Naruse, K.; Csete, M.E.; Thouless, M.D.; Takayama, S., "Cracking Fabrication of Reconfigurable Protein Matrices" Nat. Mater. 4, 403-406 (2005)
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  6. Song, J. W.; Gu, W.; Futai, N.; Warner K. A.; Nor, J. E.; Takayama, S., "A Computer-Controlled Circulatory Support System for Endothelial Cell Culture and Shearing" Anal. Chem. 77, 3993-3999 (2005)
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  7. Futai, N.; Gu, W.; Song, J.W.; Takayama, S., "Handheld Recirculation System and Customized Media for Microfluidic Cell Culture" Lab Chip 6, 149-154 (2006)
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  8. Lam, M. T.; Sim, S.; Zhu, X.; Takayama, S., "The Effect of Continuous Wavy Micropatterns on Silicone Substrates on the Alignment of Skeletal Muscle Myoblasts and Myotubes" Biomater. 27, 4340-4347 (2006)
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  9. Mehta, G.; Mehta, K.; Sud, D.; Song, J.; Bersano-Begey, T.; Futai, N.; Mycek, M.-A.; Linderman, J. J.; Takayama, S., "Quantitative Measurements and Analysis of Cellular Oxygen Uptake in Microfluidic Poly(dimethylsiloxane) Bioreactors" Biomed. Microdev. (published online) (2007)
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  10. Heo, Y. S.; Cabrera, L. M.; Smith, G. D.; Takayama, S., "Characterization and Resolution of Evaporation-Mediated Osmolality Shifts that Constrain Microfluidic Cell Culture in Poly(dimethylsiloxane) Devices" Anal. Chem. (published online) (2007)
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  11. Gu, W.; Chen, H.; Tung, Y.-C.; Meiners, J.-C.; Takayama, S., "Multiplexed Hydraulic Valve Actuation Using Ionic Liquid Filled Soft Channels and Braille Displays" Appl. Phys. Lett. (published online) (2007)
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Teaching