- Istvan J. Majoros
- Internal Medicine — Allergy
- Nanotechnology Institute for Medicine &
- Biological Sciences
- Macromolecular Science & Engineering Center
- 4027 Kresge II, 200 Zina Pitcher Pl.
- Ann Arbor, MI 48109-0533
- Tel: (734) 615-0618
- Fax: (734) 615-0621
- majoros@umich.edu
- Group Webpage
Short Biosketch
Istvan J. Majoros, Ph.D., received his M.S. in Chemical Engineering in 1971 (Technical University in Prague, Czech Republic). He earned his Ph.D. degree, which focused on Organic/Polymer Chemistry, Summa Cum Laude in 1979 (L. Kossuth University in Debrecen, Hungary). He subsequently built up extensive research experience in industry and as a faculty member of the Kossuth Lajos University in Debrecen, Hungary. From 1990-1998 he was a Visiting Professor of Polymer Science at the University of Akron in Akron, Ohio, where he synthesized highly ordered polymer structures and worked on the characterization of multi-arm star polymers. He joined the Center for Biologic Nanotechnology in 1998 as a Research Associate II and worked steadily on the design, synthesis and characterization of novel hybrid dendritic macromolecules. In 2001, he was appointed as Research Investigator in the Division of Allergy, Department of Medicine, and the Center for Biologic Nanotechnology. Dr. Majoros published over fifty peer-reviewed papers on macromolecular structures and polymer synthesis and purification. He is an internationally recognized chemical engineer and organic polymer chemist with more then twenty years of experience in research and development in organic and polymer chemistry in both academic and industrial settings. He has extensive experience in conceptualizing new molecular designs, conducting multi-step syntheses, designing technologies, and managing plants (biotechnology) with production scales of up to 150 tons isosugar per day.
Awards/Honors
- Listed in "Who's Who in Science and Engineering", Hungary (2003)
- Listed in "Who's Who in Science and Engineering", USA (2001)
- The Best Academic Poster, Rubber Mini Exposition and Technical Meeting (1995)
- Excellent Student Award of Hungarian Republic (1971)
- Scholarship for Outstanding Students from Hungarian Republic (1966-1971)
Nonprofit Consultation
Dendritech, Cambrex, Impact Analytical, and Avidimer: to support scale up synthesis of the developing dendrimer based multifunctional device for cancer.
Editorial Board
- Journal of Computational and Theoretical Nanoscience
- Muanyag es Gumi (Plastic and Rubber)
Current Research
Novel Technologies for Noninvasive Detection Diagnosis and Treatment of Cancer; To develop a new treatment for breast cancer; increasing the number of functions of the therapeutic, functionality/toxicity testing. DNA-linked dendrimer nanoparticle systems for cancer diagnosis and treatment. To develop single function dendrimer molecules linked by complementary oligonucleotides. This allows targeting, imaging, and therapeutic dendrimers to be combined into multifunctional therapeutics simply by heating mixtures of these agents above the annealing temperature of the oligonucleotide duplex.
List of Recent and Top Cited Publications
-
,
"Conventional and Living Carbocationic Polymerization United. I. A New Comprehensive Model and Diagnostic Method to Probe the Mechanism of Homopolymerizations"
Advances in Polymer Science
112,
1-114
(1994)
Times Cited:
-
,
"Conventional and Living Carbocationic Polymerizations United. II.The Conversion of Conventional to Living Isobutylene Polymerization by Proton Trap and a Comprehensive Closed Loop Mechanism of Proton Trap Mediated Living Polymerization"
J. Polym. Sci., Part A: Polym. Chem.
34(9),
1675-1683
(1996)
Times Cited:
-
,
"New Stars: Eight Polyisobutylene Arms Emanating from a Calixarene
Core"
Macromolec.
29(27),
8631-8641
(1996)
Times Cited:
-
,
"Synthesis and Characterization of Novel Well-Defined Stars Consisting of Eight Polyisobutylene Arms Emanating from an Octa(dimethylsiloxy)octasilsesquioxane Core"
Polym. Bull.
38(1),
15-22
(1997)
Times Cited:
-
,
"Acetylation of Poly(amidoamine) Dendrimers"
Macromolecules
36,
5526-5529
(2003)
Times Cited:
-
,
"Dendrimeric Supramolecular and Supramacromolecular Assemblies"
J. Macromole. Sci., Part C-Polym. Rev.
43(3),
411-477
(2003)
Times Cited:
-
,
"Targeting and Inhibition of Cell Growth by an Engineered Dendritic Nanodevice"
J. Med. Chem.
48(11),
3729-3735
(2005)
Times Cited:
-
,
"Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in
Animal Model of Human Epithelial Cancer"
Cancer Res.
65,
5317-5324
(2005)
Times Cited:
-
,
"PAMAM Dendrimer-Based Multi-Functional Engineered Nanodevice for Cancer Therapy"
J. Med. Chem.
48,
5892-5899
(2005)
Times Cited:
-
,
"PAMAM Dendrimer-Based Multi-Functional Engineered Nano-Device for Cancer Therapy II: Synthesis, Characterization, and Functionality"
Biomacromolecules
7(2),
572-579
(2006)
Times Cited:
