Macromolecular Science
and Engineering Center


  • Istvan J. Majoros
  • Internal Medicine — Allergy
  • Nanotechnology Institute for Medicine &
  • Biological Sciences
  • Macromolecular Science & Engineering Center
  • 4027 Kresge II, 200 Zina Pitcher Pl.
  • Ann Arbor, MI 48109-0533

Short Biosketch

Istvan J. Majoros, Ph.D., received his M.S. in Chemical Engineering in 1971 (Technical University in Prague, Czech Republic). He earned his Ph.D. degree, which focused on Organic/Polymer Chemistry, Summa Cum Laude in 1979 (L. Kossuth University in Debrecen, Hungary). He subsequently built up extensive research experience in industry and as a faculty member of the Kossuth Lajos University in Debrecen, Hungary. From 1990-1998 he was a Visiting Professor of Polymer Science at the University of Akron in Akron, Ohio, where he synthesized highly ordered polymer structures and worked on the characterization of multi-arm star polymers. He joined the Center for Biologic Nanotechnology in 1998 as a Research Associate II and worked steadily on the design, synthesis and characterization of novel hybrid dendritic macromolecules. In 2001, he was appointed as Research Investigator in the Division of Allergy, Department of Medicine, and the Center for Biologic Nanotechnology. Dr. Majoros published over fifty peer-reviewed papers on macromolecular structures and polymer synthesis and purification. He is an internationally recognized chemical engineer and organic polymer chemist with more then twenty years of experience in research and development in organic and polymer chemistry in both academic and industrial settings. He has extensive experience in conceptualizing new molecular designs, conducting multi-step syntheses, designing technologies, and managing plants (biotechnology) with production scales of up to 150 tons isosugar per day.

Awards/Honors

Nonprofit Consultation

Dendritech, Cambrex, Impact Analytical, and Avidimer: to support scale up synthesis of the developing dendrimer based multifunctional device for cancer.

Editorial Board

Current Research

Novel Technologies for Noninvasive Detection Diagnosis and Treatment of Cancer; To develop a new treatment for breast cancer; increasing the number of functions of the therapeutic, functionality/toxicity testing. DNA-linked dendrimer nanoparticle systems for cancer diagnosis and treatment. To develop single function dendrimer molecules linked by complementary oligonucleotides. This allows targeting, imaging, and therapeutic dendrimers to be combined into multifunctional therapeutics simply by heating mixtures of these agents above the annealing temperature of the oligonucleotide duplex.

List of Recent and Top Cited Publications

  1. Majoros I, Nagy A, Kennedy J., "Conventional and Living Carbocationic Polymerization United. I. A New Comprehensive Model and Diagnostic Method to Probe the Mechanism of Homopolymerizations" Advances in Polymer Science 112, 1-114 (1994)
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  2. Majoros I, Marsalkó T, Kennedy J., "Conventional and Living Carbocationic Polymerizations United. II.The Conversion of Conventional to Living Isobutylene Polymerization by Proton Trap and a Comprehensive Closed Loop Mechanism of Proton Trap Mediated Living Polymerization" J. Polym. Sci., Part A: Polym. Chem. 34(9), 1675-1683 (1996)
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  3. Jacob S, Majoros I, Kennedy J., "New Stars: Eight Polyisobutylene Arms Emanating from a Calixarene Core" Macromolec. 29(27), 8631-8641 (1996)
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  4. Majoros I, Marsalk— T, Kennedy J., "Synthesis and Characterization of Novel Well-Defined Stars Consisting of Eight Polyisobutylene Arms Emanating from an Octa(dimethylsiloxy)octasilsesquioxane Core" Polym. Bull. 38(1), 15-22 (1997)
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  5. Majoros I, Keszler B, Woehler S, Bull T, Baker Jr. J., "Acetylation of Poly(amidoamine) Dendrimers" Macromolecules 36, 5526-5529 (2003)
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  6. Tomalia D, Majoros I., "Dendrimeric Supramolecular and Supramacromolecular Assemblies" J. Macromole. Sci., Part C-Polym. Rev. 43(3), 411-477 (2003)
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  7. Thomas T, Majoros I, Kotlyar A, Kukowska-Latallo J, Bielinska A, Myc A, Baker Jr. J., "Targeting and Inhibition of Cell Growth by an Engineered Dendritic Nanodevice" J. Med. Chem. 48(11), 3729-3735 (2005)
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  8. Kukowska-Latallo JF, Candido KA, Cao Z, Nigavekar SS, Majoros IJ, Thomas TP, Balogh LP, Khan MK, Baker, Jr., "Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer" Cancer Res. 65, 5317-5324 (2005)
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  9. Majoros I, Thomas T, Mehta C, Baker Jr. J., "PAMAM Dendrimer-Based Multi-Functional Engineered Nanodevice for Cancer Therapy" J. Med. Chem. 48, 5892-5899 (2005)
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  10. Majoros I, Myc A, Thomas T, Mehta C, Baker Jr. J., "PAMAM Dendrimer-Based Multi-Functional Engineered Nano-Device for Cancer Therapy II: Synthesis, Characterization, and Functionality" Biomacromolecules 7(2), 572-579 (2006)
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