The research goal of our lab is to unearth fundamental mechanisms underlying the diverse and complex functions of biological systems, and to engineer them for the development of beneficial biotechnologies, through a multidisciplinary approach integrating mathematical modeling, computer simulation and wet-lab experiments. More specifically, one part of our lab focuses on the quantitative investigation of the mechanisms for biological switching, which is a widespread feature of biological systems and is crucial for the regulation of numerous biological processes, such as cell cycle progression and cell fate decision. The other research area of our lab will be the study and engineering of microorganisms with the goal of developing new biotechnologies for important applications such as bio-energy and bio-remediation. Examples of interesting projects in this broad direction include system-level modeling of metabolic networks, design and construction of genetic circuits, and laboratory evolution of microbial consortia.

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