Kirschner DE, Linderman JJ. Mathematical and computational approaches can complement experimental studies of host-pathogen interactions. Cellular Microbiol in press.
Linderman JJ. Modeling of G-protein coupled receptor signaling pathways. J Biol Chem in press.
Brinkerhoff CJ, Traynor JR, Linderman JJ. Collision coupling, crosstalk, and compartmentalization in G-protein coupled receptor systems: Can a single model explain disparate results? J Theor Biol 255: 278-286, 2008.
Chang ST, Linderman JJ, Kirschner DE. The effect of multiple polymorphisms on antigen presentation and susceptibility to M. Tuberculosis infection. Infection Immunity 76: 3221-3232, 2008.
Clark MJ, Linderman JJ, Traynor JR. Endogenous RGS proteins differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model. Molec Pharmacol 73: 1538-1548, 2008.
Brinkerhoff CJ, Choi JS, Linderman JJ. Diffusion-limited reactions in G-protein activation: Unexpected consequences of agonist and antagonist competition. J Theor Biol 251: 561-569, 2008.
Riggs T, Walts A, Perry N, Bickle L, Lynch JN, Myers A, Flynn J, Linderman JJ, Miller MJ, Kirschner DE. A comparison of random vs. chemotaxis driven contacts of T cells with dendritic cells during repertoire scanning. J Theor Biol 250: 732-751, 2008.
Thwar P, Linderman JJ, Burns MA. Electrode-less DC dielectrophoresis using reconfigurable field-shaping oil barriers. Electrophoresis 28: 4572-4581, 2007.
Comisar W, Kazmers NH, Mooney DJ and Linderman JJ. Engineering RGD nanopatterned hydrogels to control preosteoblast behavior: A combined computational and experimental approach. Biomaterials 28: 4409-4417, 2007.
Mehta G, Kiel MJ, Lee JW, Kotov N, Linderman JJ, Takayama S. Polyelectrolyte-clay-protein layer films on microfluidic PDMS bioreactor surfaces for primary murine bone marrow culture. Adv Functional Materials 17: 2701-2709, 2007.
Kirschner DE, Chang ST, Riggs T, Perry N, Linderman JJ. Toward a multi-scale model of antigen presentation in immunity. Immunological Rev 216: 93-118, 2007.
Mehta G, Mehta K, Sud D, Song J, Bersano-Begey T, Futai N, Mycek M, Linderman JJ, Takayama S. Quantitiative oxygen measurements and analysis of cellular oxygen uptake in microfluidic poly(dimethylsiloxane) bioreactors. Biomedical Microdevices 9: 123-134, 2007.
Kinzer-Ursem TL, Linderman JJ. Both ligand- and cell-specific parameters control ligand agonism in a kinetic model of G protein coupled receptor signaling. PLOS Computational Biol 3: e6, 2007.
Thwar PK, Guptaroy B, Gnegy ME, Burns MA, Linderman JJ. A simple transporter trafficking model for amphetamine-induced dopamine efflux. Synapse 61: 500-514, 2007.
Brinkerhoff, C, and Linderman, JJ, “Integrin dimerization and ligand arrangement: Key components in integrin clustering for cell adhesion”, Tissue Engineering 11: 865-876, 2005.
Chang, ST, Linderman, JJ, and Kirshner, DE, “Multiple mechanisms allow Mycobacterium tuberculosis to continuously inhibit MHC class II-mediated antigen presentation by macrophages”, PNAS 102: 4530-4535, 2005. This paper was highlighted in the “Research Roundup” feature of the Journal of Cell Biology (“TB bug inhibits any which way”, J. Cell Biol. 168: 896, 2005).
Chang, PS, Axelrod, D, Omann, GM, and Linderman, JJ, “G-protein threshold behavior in the human neutrophil oxidant response: Measurement of G-proteins available for signaling in responding and nonresponding subpopulations”, Cellular Signalling 17: 605-614, 2005.
Brinkerhoff, CJ, Woolf, PJ, and Linderman, JJ “Monte Carlo Simulations of Receptor Dynamics: Insights into Cell Signaling, J. Molec. Histology 35: 667-677, 2004.
Lee, KY. Alsberg, E, Hsiong, S, Comisar, W, Linderman, J, Ziff, R, and Mooney, D, “Nanoscale adhesion ligand organization regulates osteoblast proliferation and differentiation”, Nano Letters 4: 1501-1506, 2004.
Waller, A, Sutton, KL, Kinzer, TL, Absood, A, Linderman, JJ, and Omann, GM, “Receptor binding kinetics and cellular responses of six N-formyl peptide agonists in human neutrophils”, Biochemistry 43: 8204-8216, 2004.
Woolf, PJ. and Linderman, JJ, “An algebra of dimerization and its physiological implications for G-protein coupled receptor signaling”, J. Theor. Biol. 229: 157-168, 2004.
Chang, PS. Absood, A, Linderman, JJ, and Omann, GM, “Magnetic Bead Isolation of Neutrophil Plasma Membranes and Quantification of Membrane-Associated Guanine Nucleotide Binding Proteins”, Analytical Biochemistry 325: 172-184, 2004.
Woolf, P.J., and Linderman, J.J., “Self organization of membrane proteins via dimerization”, Biophysical Chemistry 104: 217-233, 2003.
Zhong, H., Wade, S.M., Woolf, P.J., Linderman, J.J., Clark, M.J., Traynor, J.R., and Neubig, R.R., “A spatial focusing model for G protein signals: RGS protein-mediated kinetic scaffolding”, J. Biological Chemistry 278: 7278-7284, 2003.
Keil,M.L., Solomon,N.L., Lodhi, I.J., Stone, K.C., Jesaitis, A., Chang,P.S., Linderman, J.J., and Omann, G.M., “Priming-induced localization of Gia2 in high density membrane microdomains”, Biochem. Biophys. Res. Commun. 310: 862-872, 2003.
Shim, J., Bersano-Begey, T.F., Zhu, X., Tkaczyk, A.H., Linderman, J.J., and Takayama, S., “Micro- and nanotechnologies for studying cellular function”, Current Topics in Medicinal Chemistry 3: 339-353, 2003.
Woolf, P.J., and Linderman, J.J., “Untangling ligand induced activation and desensitization of G-protein coupled receptors”, Biophysical J 84: 3-13, 2003.
Cunningham, J.J., Linderman, J.J., and Mooney, D.J., “Externally applied cyclic strain regulates focal contact composition in cultured smooth muscle cells”, Annals of Biomedical Engineering 30: 927-935, 2002.
Cunningham, J.J.. Nikolovski, J., Linderman, J.J., and Mooney, D.J. “Quantification of fibronectin adsorption to silicon rubber substrates”, BioTechniques 32: 876-878, 2002.
Waller, A.W., Pipkorn, D., Sutton, K.L., Linderman, J.J., and Omann, G.M., and Linderman, J.J., “Validation of flow cytometric competitive binding protocols and characterization of fluorescently labeled ligands”, Cytometry 45: 102-114, 2001.
Woolf, P.J., Kenakin, T.P., and Linderman, J.J., “Uncovering biases in high throughput screens of G-protein coupled receptors”, J. Theoretical Biology 208: 403-418, 2001.
Shea, L.D., Neubig, R.R., and Linderman, J.J., “Timing is everything: The role of kinetics in G protein activation”, Life Sciences 68: 647-658, 2000.
