Omolola Eniola-Adefeso Assistant Professor 3412 G.G. Brown (734) 936-0856 FAX: (734) 764-7453 lolaa@umich.edu Cell adhesion and migration, vascular biology, drug targeting/delivery, biomaterials for drug delivery Short Bio Research Publications Teaching Group Page

Research Interests

Due to their high specific interaction with their counter-receptors and their carefully regulated expression (limit to inflammation), leukocyte-endothelium adhesion molecules (LECAM) are attractive molecules for vascular targeting in human diseases in which inflammation plays a role. Our research goal is to use knowledge of the cellular inflammatory response and blood flow dynamics to design bio-functionalized particles for targeted drug delivery and imaging.

Work in the lab is divided into 3 major groups:

1. Cell Adhesion and Migration – Cells of the immune system.
   Our goal is to use in vitro experimental setups to understand the receptor-ligand interactions involved in leukocyte firm arrest and transmigration.
   
   
2. Design of polymeric cells for targeted drug delivery. We are working on designing sophisticated leukocyte mimetics that can target therapeutics to diseased vasculature via multiple receptor-ligand interactions with applications in cardiovascular disease and cancer.
   
   
3. Smart Biomaterials for Drug Delivery. We working closely with polymer chemists and material scientist to identify new materials for drug delivery. Our work in this area is currently focused on immune response to new materials.