Faculty and Research News
 6-Mercaptopurine and its riboside derivatives are some of the most widely utilized anti-leukemic and anti-inflammatory drugs however their short biological half-life and severe side effects limit their use. Nicholas Kotov and two researchers from his group, Paul Podsiadlo and Vladimir Sinani, have developed a small, metallic gold-nanoparticle-based carrier for 6-mercaptopurine-9-β-D-ribofuranoside, a prodrug of 6-mercaptopurine with a goal of improving the drug’s effectiveness. In vitro experiments with Human Leukemia Cells showed that this new delivery system has improved efficacy over the free drug in solution.
Their research is featured in the January 15 issue of Langmuir.
Free-standing, 300-bilayer PVA/MTM composite film showing high flexibility and transparency
Nick Kotov, graduate student Paul Podsiadlo, and other U-M researchers created a composite plastic that’s as strong as steel but lighter and transparent. It’s made of layers of clay nanosheets and a water-soluble polymer that shares chemistry with white glue. Kotov and his collaborators are authors of a paper on this composite material published in the October 5, 2007 edition of Science. (2007)
Read full story from U-M News Service
 The Department of Chemical Engineering is proud to announce that Professor H. Scott Fogler was elected the national president of the American Institute of Chemical Engineers (AIChE). Scott will serve as president-elect from January 1, 2008 - December 31, 2008, and as president, January 1, 2009 - December 31, 2009. We know he will continue to be proactive to move AIChE forward. (2007)
 Results of work done by chemical engineering graduate student Weixian Shi and his advisor, Ron Larson were published in the June 2007 issue of Biochemical and Biophysical Research Communications. Mr. Shi and Dr. Larson found that using atomic force microscopy (AFM), allowed them to discover RecA-single-stranded DNA (RecA-ssDNA) filaments, in the presence of single-stranded DNA-binding (SSB) protein, mostly organized into left-handed bundles. This finding differs from the previously reported disordered aggregates formed when SSB is excluded from the reaction. In addition, they observed both left-and right-handedness on bundles of two filaments." (2007)
 Suljo Linic has been selected to receive this year's departmental excellence award for outstanding research, service, and teaching. He will be honored at the 2008 College Dinner Dance. Congratulations Professor Linic! (2007)
 Recent advances in nano-biotechnology are leading to the design of functional probes that are able to self-orient relative to a cell surface, thereby encoding-and ultimately revealing-useful biological information. Many methods have been reported on the fabrication of anisotropic particles, such as Janus particles--two-sided particles with different material compositions in each side. Jeorg Lahann and two researchers from his group, Mutsumi Yoshida and Kyung-Ho Roh, have pursued an alternative route toward the design and synthesis of polymer-based nanoparticles with two or multiple distinct phases, using electrified co-jetting. (2007)
The team's findings are the cover article the the May 8 issue of Langmuir.
 Ralph T. Yang has been selected to receive a 2006-2007 University of Michigan Distinguished Faculty Achievement Award. The award honors senior faculty who have consistently demonstrated outstanding achievements in the areas of scholarly research and/or creative endeavors, teaching and mentoring of students and junior faculty, service and a variety of other activities which have brought distinction to themselves and to the University. Congratulations Professor Yang! (2007)
 Sharon C. Glotzer has been selected to receive a 2006-2007 Faculty Recognition Award from the University of Michigan. The award is intended for faculty in the earlier phase of their careers who have demonstrated sub-stantive contributions to the University through significant achievements in scholarly research and/or creative endeavors; excellence as a teacher, advisor and mentor; and distinguished participation in the service activities of the University. Congratulations Professor Glotzer (2007)
Scientists Discover Rules for Some Common Virus Shapes
 A surprising discovery at the University of Michigan about how nanoparticles self-assemble into structures that resemble viruses gives scientists key insight into how common disease producing viruses might form in our bodies.
This new understanding brings researchers closer to making synthetic virus-like particles in the lab that could be used to help stop viruses from replicating, or could be used as stealth viruses to deliver drugs.
Using computer simulations, chemical engineering PhD student Ting Chen, research associate Zhenli Zhang, and Professor Sharon Glotzer self-assembled tiny particles into precise, convex shapes. (2007)
The team's findings are published in the Proceedings of the National Academy of Science.
("A precise packing sequence for self-assembled convex structures," Chen, et al, PNAS, January 16, 2007, 104, 3, pp. 717-722.)
 Professor Phillip Savage received a College of Engineering Education Excellence Award in recognition of his outstanding classroom teaching, his work with undergraduate students in research, his excellent graduate mentoring, his integration of research into classroom teaching, and his service related to education.(2007)
 Polymers, large molecules comprised of chains of repeating structures, are used in everything from the coatings on walls of ships and pipes to reduce flow drag to gene therapy. (Image courtesy of Proceedings of the National Academy of Sciences) But long polymer chains are subject to breakage, called scission, and a new study conducted by Michael Solomon, Steven Ceccio, from the Department of Mechanical Engineering and Naval Architecture and Marine Engineering, and former ChE doctoral student, Siva Vanapalli, shows that as it turns out, much of what scientists previously thought about why polymers break when subjected to strong flows, such as waves crashing against a ship's bow, was wrong. (2006)
Their research results appeared in a recent issue of Proceedings of the National Academy of Sciences. (From U-M News Service)
"Universal scaling for polymer chain scission in turbulence," Vanapalli, S. A. , S. L. Ceccio, and M. J. Solomon, PNAS 2006 103: 16617-16618.
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