ChE 344 Reaction Engineering and Design

Biol 311 Introductory Biochemistry or equivalent.

DATE OF PREPARATION: Last Revision: 3/29/99

FACULTY APPROVAL: 3/29/99

Concepts necessary in the adaptation of biological and biochemical principles to industrial processing in biotechnology and pharmaceutical industries. Topics include rational screening, functional genomics, cell cultivation, oxygen transfer, etc. Lectures, problems, internet, and library study will be used.

1. Introduction to bioprocesses and bioproducts (3)

2. Rational drug screening using enzyme inhibitors as models (3)

3. Applied molecular genetics (5)

4. Rational medium design and optimization (3)

5. Cell growth kinetics (3)

6. Batch, fed-batch and continuous cultures (3)

7. Oxygen transfer (3)

8. Bioreactor design and scale translation (5)

9. Bioinstrumentation and control (2)

10. Biomanufacturing facility design and operation (5)

11. Industrial site visits (3)

1. To expose students to career opportunities in pharmaceutical, biotechnology and natural resources industries. [1]

2. To teach students how to utilize chemical engineering principles in bio-related problems.[2,3,4,5,6,7]

3. To teach students some applied cellular and molecular biology concepts.[3,4,5,6,7,11]

4. Provide experiences for students to develop knowledge in biotechnology through independent projects.[9,10,11]

5. Provide experiences for students to practice oral and written communication skills [9,10,11]

6. To prepare students to make ethical decisions in biotechnology[8]

COURSE

OUTCOMES

1. Find information on careers in pharmaceutical, biotechnology and natural resources industries.[9]

4. Solve problems on material and energy balances in medium design.[1,3,5,12,13]

5. Solve problems on cell growth kinetics and product formation using spreadsheet.[1,5,11-13]

6. Solve problems on oxygen transfer and reactor design and scale translation.[1,5,12,13]

7. Solve problems on cell death and sterilization kinetics.[1,5,12,13]

8. Use various ethical decision making tools to make decisions .[6]

9. Identify bioprocesses and bioproducts in pharmaceutical and biotechnology related industries.[10,12,13]

10. Identify bioprocesses and bioproducts in pollution prevention and environmentally related fields.[10,12,13]

11. Identify current advances in biomedicine and biopharmaceutical related fields.[10,12]

2. Problem sets assess outcomes 1-8 for individual students

3. Term project (with report and presentation) on bio-related subject selected by the students assesses outcomes 9 - 11.

4. End-of-term course evaluation provides student self-assessment of outcomes 1-11