Patents:

 USP 4,869,826 (9/26/1989)  Cellular Adsorbents For Removal of Viral Contaminants From Blood and  Complex Protein Solutions (with I. Fu Tsao).

 USP 4,921,340 (5/1/1990)  Dissolved Oxygen Measuring System (with X. M. Li).

 USP 5,093,256 (3/3/1992) Essentially Purified, Thermostable and Alkaliphilic Lipase from Bacillus spp.
 (with G.J. Shen et al.).

 USP 5,427,935 (6/27/1995) Hybrid Membrane Bead and Process for Encapsulating Material in Semi- Permeable Hybrid Membranes. (with S.C. Nigam).

 USP 5,635,393 (6/3/1997) Method for Dechlorinating Polychlorinated Biphenyls and Granules for Use in  Method. (with L. Bhatnagar et al ).
 
 

Peer Reviewed Publications:

Wang, H.Y., D.G. Mou and J.R. Swartz.  "Thermodynamic Evaluation of Microbial Growth."  Biotech. Bioeng., Vol. 18, 12, p. 1811-1814, 1976.

Cooney, C.L., H.Y. Wang and D.I.C. Wang.  "Computer-Aided Bakers' Yeast Fermentations,"  Biotech. Bioeng., Vol. 191, p. 69-86, 1977.

Wang, H.Y.,  Cooney, C.L.,  and D.I.C. Wang.  "The Application of Dynamic Calorimetry of Monitoring Growth of Saccharomyces cerevisiae," European Journal of Appl. Micro. and Biotech., 5, p. 207-214, 1978.

Wang, H.Y., C.L. Cooney and D.I.C. Wang.  "Computer Control of Bakers Yeast Fermentation,"  Biotech. Bioeng., Vol. 21, 6, p. 975-995, 1979.

Wang, H.Y.  "Volume Changes During Aerobic Fermentation," Biotech. Bioeng., Vol. 21, 3, p. 525-532, 1979.

Wang, H.Y., C.L. Cooney and D.I.C. Wang.  "On-Line Gas Analyses for Material Balances and Control," Biotechnol. Bioeng. Symp. 8, 1979.

Wang, H.Y., L.A. Kominek and J.L. Jost.  "On-Line Extraction Fermentation Processes," The Proceedings of the VI International Fermentation Symposium, London, Canada, Vol. 1, 601, 1981.

Lee, S.S., F.M. Robinson and H.Y. Wang.  "Rapid Determination of Yeast Viability," Biotech. Bioeng. Symp., 11, 641, 1981.

Wang, H.Y.  "Application of Polymeric Resisns as Means in Microbiological Assay," Developments in Industrial Microbiology, Vol. 22, 739, 1981.

Wang, H.Y., F.M. Robinson and S.S. Lee.  "Enhanced Alcohol Production Through On-Line Extraction," Biotech. Bioeng. Symp., 11, 555, 1981.

Wang, H.Y. and D.J. Hettwer.  "Cell Immobilization in K-Carrageenan with Tricalcium Phosphate," Biotech. Bioeng., 24, 1827, 1982.

Seaton, J.J. and H.Y. Wang.  "Fermentation Monitoring by Polymeric Resin Based Microbial Assay,"  Biotech. Bioeng., 25, 771, 1982.

Lee, S.S. and H.Y. Wang.  "Repeated Fed-Batch Fermentaion Using Yeast Cells and Activated Carbon Extraction System," Biotech. Bioeng. Symp. 12, 221, 1982.

Wang, H.Y., S.S. Lee, Y. Takach and L. Cawthorn.  "Maximizing Microbial Cell Loading in Immobilized Cell Systems," Biotech. Bioeng.  Symp., 12, 139, 1982.

Wang, H.Y.  "Interaction Between Fermentation and Subsequent Product Recovery Processes," Annals of the New York Academy of Sciences, 413, 1983.

Wang, H.Y.  "Fermentation Gas Analyses," in Comprehensive Biotechnology, Vol. 4, p. 423-431, edited by M. Moo-Young, 1986.

Wang, H.Y., G.F. Payne and F.M. Robinson.  "Immobilized Product Fermentation Processes," Proceedings of the 33rd Canadian Chemical Engineering Conference, Vol. 2, Toronto, Canada, 1983.

Evans, P.J. and H.Y. Wang.  "Pigment Production from Immobilized Monasus supp. Utilizing Polymeric Resin Adsorption," Appl. Enviorn. Microbiol. 47, 1323-1326, 1984.

Kominek, L.A., H.Y. Wang and J.L. Jost.  "Cycloheximide Fermentation," Chapter in the Production of Antibiotics by Fermentaion Processes, edited by  E.J. Vandame,  pp. 531-550, 1984.

Wang, H.Y.  "Sensor Development for Fermentation Monitoring and Control," Biotechnol. Bioeng. Symp., 14, 601, 1984.

Wang, H.Y. and K. Sobnosky.  "Design of a New Affinity Adsorbent for Biochemical Product Recovery," In ACS Symposium on  "Recovery and Purification processes for Fermentation Products," edited by Leroith, et al., Vol. 271, 123, 1985.

Wang, H.Y.  "Bioinstrumentation and Computer Control of Fermentation Processes," ASM Manual on "Industrial Microbiology," edited by A.L. Demain and N.A. Soloman, p. 308-320, American Society of Microbiology, 1986.

Wang, H.Y., G.. F. Payne and F.M. Robinson.  "Computer Control of Immobilized Product Fermentation," Proceedings of the 1st IFAC Symposium on "Modelling and Control of Biotechnological Processes," Noordwijkerhout, the Netherlands, pp. 49-53, 1986.

Liang, B.S., X.M. Li and H.Y. Wang.  "Cellular Electrode for Antitumor Drug Screening,"  Biotechnol. Progress 2: 187-191, 1986.

Dykstra, K. and H.Y. Wang.  "Dynamic Modeling of On-Line Extractive Fermentations," Proceedsings of World Congress III of Chemical Engineering, Vol. 1, 909-912, 1986.

Li, X.M., B.S. Liang and H.Y. Wang.  "Mathematical Modeling of Immobilized Cellular Electrodes," Proceedings of the 3rd Wold Congress of Chemical Engineering, Vol. I, p. 859-862, 1986.

Kelley, J., G.Y. Wang and H.Y. Wang.  "Assessment of Large-Scale Gel Chromatography for Purification of Protein Products," ACS Symposium on Separation, Recovery and Purification in Biotechnology, edited by J.A. Asenjo and J. Hong, 314, 193-207, 1986.

Nigam, S.C. and H.Y. Wang.  "Mathematical Modeling of Bioproducts Adsorption Using Immobilized Affinity Adsorbents," ACS Symposium on Separation, Recovery and Purification in Biotechnology, edited by J.A. Asenjo and J. Hong, 314, 151-168, 1986.

Hettwer, D.J. and H.Y. Wang.  "Protein Release from Chemically Permeabilized Escherichia coli," ACS Symposium on Separation, Recovery and Purification in Biotechnology, edited by J.A. Asenjo and J. Hong, 314, 2-8, 1986.

Li, X.M and H.Y. Wang.  "Transient D.O. Measurement Using a Computerized Membrane Electrode," In Horizons of Biochemical Engineering.  S. Aiba (ed.), p. 213-221, University of Tokyo Press, 1987.

Wang, H.Y. and J.J. Seaton.  "Increased Sensitivity and Discrimination in Screening through an Immobilized-Resin Microbiological Assay Method," J. Ind. Microbial,., 2:243-249, 1987.

Evans, P.J. and H.Y. Wang.  "Response of Clostridium acetobutylicum to the Presence of Mixed Extractants," Appl. Biochem. and Biotechnol., 16, 175-192, 1987.

Dykstra, K.H. and H.Y. Wang.  "Change in the Protein Profile of Streptomyces griseus during a Cycloheximide Fermentation," Annals of the New York Academy of Science, 506:511-522, 1987.

Li, X.M., B.S. Liang and H.Y. Wang.  "Computer Aided Analysis for Biosensing and Screening," Biotechnol. Bioeng., 31, 256-259, 1988.

Hettwer, D.J. and H.Y. Wang.  "Protein Release from Chemically Escherichia coli Permeabilized with Guanidine HCl and Ticton X-100," Biotechnol. Bioeng., 33, 886-895, 1988.

Dykstra, K.H. , X.M. Li and H.Y. Wang.  "Computer Modeling of an Antibiotic Fermentation with On-Line Product Removal,"  Biotechnol. Bioeng., 32:356-362, 1988.

Wang, H.Y., R.J. Lawless and J.E. Lin.  "Use of Membrane Oxygenation to Increase Oxygen Transfer Capacity of a Bioreactor," Process Biochemistry, 23, 1:23-27, 1988.

Li, X.M., R.M. Schwartz, E.Y. Cesar and H.Y. Wang.  "An Integrated Microcomputer System Using Immobilized Cellular Electrodes for Drug Screening," Computers in Biology and Medicine, 18, 367-376, 1988.

Nigam, S.C., A. Sakoda and H.Y. Wang.  "Bioproduct Recovery from Unclarified Brothes and Homogenates Using Immobilized Adsorbents," Biotechnology Progress, 4, 166-172, 1988.

Nigam, S.C., I.F. Tsao, A Sakoda and H.Y. Wang.  "Encapsulation of Bioactive Materials in Semi-Permeable Membranes," Biotechnology Techniques, 2:4, 271-276, 1988.

Tsao, E., C. Shipman, Jr. and H.Y. Wang.  "Removal of Viral Contaminants Using A Cellular Adsorbent: A Feasibility Study."  Bio/Technology, 11, 1330-1333, 1988.

Evans, P.J. and H.Y. Wang.  "Enhancement of Butanol Formation by Clostridium acetobutyricum in the Presence of Decanol-Oleyl Alcohol Mixed Extractants," Appl. Environ, Microbiol., 54, 7:1662-1667, 1988.

Payne, G.F. and H.Y. Wang.  "Phosphate Feeding to Permit Growth While Maintaining Secondary Metabolite Synthesis."  Appl. Microbiol. Botechnol., 27:572-576, 1988.

Tsao, I.F., H.Y. Wang and C. Shipman, Jr.  "Interaction of Infectious Viral Particles With A Surface-Bonded Quaternary Ammonium Chloride," Biotechnol. Bioeng., 34:4, 639, 1989.

Payne, G.F. and H.Y. Wang.  "The Effect of Feedback Regulation and In-situ Product Removal on Sugar Consumption for Secondary Metabolite Production," Arch. Microb., 151:331-335, 1989.

Wang H.Y., P.J. Evans, K. Dykstra, S.C. Nigam and G.S. Hyatt.  "Application of Affinity Adsorption in Antibiotic Fermentations."  In Advances in Biochemical Engineering/Biotechnology, ed., by A. Fiechter et. al., p. 267-277, 1989.

Palanki, S., X.M. Li, C. Kravaris and H.Y. Wang.  "Transient Measurements and Analyses of Biosensors," AIChE Symposium Series: Process Sensing and Diagnostics, ed. by J.J. Ulbrecht, 267, 85: 100-105, 1989.

Sakoda, S. and H.Y. Wang.  "A New Isolation and Purification Method for Staphylococcal Protein A Using Membrane Encapsulated Rabbit lgG-Agarose."  Biotechnol. Bioeng., 34:8, 1098-2002, 1989.

Imanaka, T., A. Kuroda and H.Y. Wang.  "Protein Engineering of Penicillinase as Affinity Ligands for Bioprocessing," J. Ferment. Bioeng, 67:5,  315-320, 1989.

Nigam, S.C. and H.Y. Wang.  "Recovery of Bioactive Molecules and Recombinant Proteins from Heterogenous Culture Media."  In New Directions in Sorption Technology,  ed. George Keller III and R. Yang, 241-256, 1989.

Wang, H.Y. and X.M. Li.  "Transient D.O. Measurement Using Membrane Electrodes."  Biosensors, 4, 273-285, 1989.

Wang, H.Y., S. Palanki, and G.S. Hyatt.  "Application of Affinity Adsorption in Thienamycin Fermentation."  Appl. Microbiol. Biotechnol. 30, 115-119, 1989.

Tsao, I-Fu and H.Y. Wang.  "Removal and Inactivation of Viruses by A Surface Bonded Quaternary Ammonium Chloride," in ACS Symposium Series 419 on Novel Bioseparations edited by J. Hamel et. al., 13, 250-267, 1990.

Naglak, T., D.J. Hettwer and H.Y. Wang.  "Chemical Permeabilization of Cells for Intracellular Product Release," In Separation Processes in Biotechnology, ed. J.A. Asenjo, 177-205, 1990.

Evans, P.J. and H.Y. Wang.  "Effects of Extractive Fermentation on Butyric Acid Production by Clostridium acetobutylicum." European J. Appl. Microbiol. and Biotechnol. 32, 393-397, 1990.

Mohan, K.K., I-Fu Tsao, and H.Y. Wang.  "Conceptual Design of A Cellular Filter to Remove Trace Viral Contaminants from Blood."  Biotechnol. Progress, 6:104-113, 1990.

Lin, J.E., R. Hickey and H.Y. Wang.  "Biodegradation Kinetics of Pentachlorophenol by Phanerochaete Chrysosporium: Effects of PCP, Extracellular Enzymes and Cell Concentrations," Biotechnol. Bioeng., 35:1125-1134, 1990.

Lin, J.E., R.F. Hickey, G.J. Shen, and H.Y. Wang.  "Co-Immobilized Systems for the Biodegradation of Toxic Chemicals" in Biotechnology Applications in Hazardous Waste Treatment, ed. by G. Lewandowski, 1990.

Sakoda, A., S.C. Nigam and H.Y. Wang.  "Affinity Extraction Using Membrane Encapsulated Polymer-Ligand Derivatives."  Enzyme and Microbial Technol. 12, 349-354, 1990.

Nigam, S.C., A.R. Siahpush and H.Y. Wang.  "Analyses of Bioproduct Separation Using Gel Enclosed Adsorbents."  AIChE J., 36:8, 1239-1248,  1990.

Dykstra, K.H. and H.Y. Wang. "Feedback Regulation and the Intracellular Protein Profile of Streptomyces griseus
in A Cycloheximide Fermentation." Appl. Microbiol. Biotechnol., 34:191-197, 1990.

Wang, H.Y., M. Zhang and T. Imanaka. "Screening and Separation of Beta-lactam Antibiotics Using Protein Engineered Enzymes." Ann. N.Y. Acad. Sci. 613: 376-384, 1990.

Naglak, T.J. and H.Y. Wang, "Recovery of A Foreign Protein From the Periplasm of Escherichi coli by Chemical Permeabilization," Enzyme and Microbial Technol., 12:603-611, 1990.

Wu, X.Y.,Y. Guan, Gan Wei and H.Y. Wang, " Theoretical Equations for Agar-Diffusion Bioassay" Ind. Eng. Chem.29:1731-1734, 1990.

Naglak, T.J. and H.Y. Wang, "Protein Release from the Yeast Pichia Pastoris by Chemical Permeabilization: Comparison to Mechanical Disruption and Enzymatic lysis" Separation for Biotechnology 2 ed. by D.L. Pyle,
p. 55-64, Elsevier, London, 1990.

Lin, J.E.,  D.C.N. Chang,G.J. Shen and H.Y. Wang.  "Correlation Among Several Screening Methods Used for Identifying Wood-Decay Fungi that can Degrade Toxic Organic Chemicals."  Biotechnol. Techniques,5:4,275-280 1991.

Lin, J.E., R. Hickey and H.Y. Wang.  "Use of Co-Immobilized Biological Systems to Degrade Toxic Organic Compounds," Biotechnol. Bioeng., 38:273-279, 1991.

Lin J.E. and H.Y. Wang. "Degradation of Pentachlorophenol by Non-immobilized, Immobilized and Co-immobilized Arthrobacter Cells" J. Ferment. Bioeng. 72 (4), 311-314, 1991.

Hatzinikolaou, D.G. and H.Y. Wang.  "Quantitative Evaluation of the pH Profile in Organic Acid Fermentations."  Biotechnology Bioeng., 37: 190-195, 1991.

Hatzinikolaon, D.G., and H.Y. Wang.  "Extractive Fermentations For Organic Acids Production."  Canadian J. Chem. Eng., 70:543-552,1992.

Wang, H.Y.,  T. Eisfeld, and A. Sakoda..  "A New Approach for Cell Encapsulation,"  in "Biologicals from Recombinant Microorganisms and Animal Cells"  ed. by M.D. White et al, VCH publishers, Weinheim, p.173-182,  1991.

Naglak, T.J. and H.Y. Wang. "Rapid Protein Release from Escherichia coli by Chemical Permeabilization under Fermentation Conditions." Biotechnol Bioeng. 39:732-740, 1992.

Chen, J.C., T.J. Naglak and H.Y. Wang. "An Amperiometric Alcohol Sensor Based on Chemically Permeabilized Methylotrophic Microorganisms" Biotechnol Progress, 8:161-164, 1992.

Siahpush, A.R., J.E. Lin and H.Y. Wang. "Effect of Adsorbents on Degradation of Toxic Organic Compounds by Co-immobilized Systems." Biotechnol Bioeng. 39:619-628, 1992.

Wang, H.Y. and K.H. Dykstra." Application of 2-D Gel Electrophoresis to Study Intracellular Events in Industrial Organisms" Proceedings of 3rd U.S./Japan Conference on Biotechnology, 177-191, 1992.

Dykstra, K.H. and H.Y. Wang. " Monitoring Intracellular Protein Profiles with Two-Dimensional Gel Electrophoresis"  Biotechnol Progress, 8:369-374, 1992.

Wang, H.Y. and M. Zhang. " Molecular Design and Construction Of Affinity Ligands Using Engineered Enzymes" in Biochemical Engineering for 2001, p. 602-605  ed. by S. Furusaki et al, Springer-Verlag, Tokyo, 1992.

Chen, J.C. and H.Y. Wang. " Bioprocess Monitoring of Dissolved Oxygen Using A Computerized Pulsing Membrane Electrode"  Biotechnol. Progress, 9:75-80, 1993.

Park, J.K., H.Y. Wang and H.N. Chang."Adsorption Behavior of Albumin and Beta-Lactamase in Alginate-Encapsulated DEAE-Trisacryl Beads" J. of Chem. Eng. of Japan, 26:317-320, 1993.

Wu, W.M., M.R. Natarajan, J. Nye, C. Kennes, R.F. Hickey, H. Wang and L. Bhatnagar. "Reductive Dechlorination of Chlorinated Organic Compounds by Anaerobic Microbial Consortia" In Proceedings of the 9th International Conference on Advanced Science and Technology, ed. by Y.F. Chang, CAPAMA, Motorola Inc., p.170-175, 1993.

Palanki, S., C. Kravaris and H.Y. Wang.  "Synthesis of State Feedback Laws for End-point Optimization in Batch Processes." Chem. Eng. Sci., 48:135-152, 1993

Palanki, S., C. Kravaris and Henry Y. Wang. "Optimal Feedback Control Of Batch Reactors With A State Inequality Constraint and Free Terminal Time", Chem. Eng. Sci., 49:85-97, 1994.

Siahpush, A.R., R.F. Hickey and H.Y. Wang." Surfactant Mediated Biotransformation and Degradation of Sparingly Soluble Compounds" In Proceedings of the Third Asia-Pacific Biochemical Engineering Conference, June 13-15, Singapore,1994.

Wang, H.Y., W.M. Wu, M.R. Natarajan, R.F. Hickey, L. Bhatnagar and M. Jain." Reductive Dechlorination of Chlorinated Organic Compounds by Anaerobic Methanogenic Granules" In Proceedings of the Third Asia-Pacific Biochemical Engineering Conference, June 13-15, Singapore, 1994.

Srinivasan, K.R. and H.Y. Wang. Proceedings of the Joint Symposium on Envrionemntal Engineering by Canadian and American Societies of Civil Engineering,  Montreal, Quebec, Vol II, 1111, 1994.

Zhang, M. and H.Y. Wang. "Hydrogen Peroxide Production Using Chemically Treated Pichia pastoris Cells", Enzyme and Microbial Technology, 16:10-17, 1994.

Wang, Y.X., K.C. Srivastava, G.W. Shen and H.Y. Wang. "Thermostable Alkaline Lipase from a Newly Isolated Thermophilic Bacillus Strain A30-1 (ATCC 53841). J. Ferment. Bioeng. 79:433-438, 1995.

Natarajan, M.T., H. Wang, R. Hickey and L. Bhatnagar. "Effect of Oxygen and Storage Conditions on the Metabolic and Dechlorination Activities of Anaerobic Biomethanogenic granules" Applied Microbiol. Biotechnol., 43:733-738, 1995.

Natarajan, M.R., W.M. Wu, R. Rajan, J. Nye, H. Wang and M. K. Jain. “Dechlorination of PCBs by Anaerobic Microbial Granules”, in Organohlaogen Compounds, vol.24, p. 33-36, ed. P. Adriaens et al, Proceedings of the 15th International Symposium on Chlorinated Dioxins and Related Compounds, Edmonton, Alberta, Canada, 1995.

Wang, H.Y. and T. Imanaka (ed.) Antibody Expression and Engineering, ACS Symposium series 604, 143 pp., 1995.

Natarajan, M.T., W.M. Wu, J. Nye, H. Wang, L. Bhatnagar and M.K. Jain. "Dechlorination of Polychlorinated Biphenyl Congeners by An Anaerobic Microbial Consortium" Appl. Microbiol. Biotechnol., 46:673-677, 1996.

Wang, H.Y. "Recent Advances in Bioproducts and Bioprocesses" in Recent Innovation in Biomanufacturing, UNESCO, Bangkok, Thailand, 1996.

Wang, H.Y. "Biomanufacturing Concept and Technologies" in Recent Innovation in Biomanufacturing, UNESCO, Bangkok, Thailand, 1996.

Wang, H.Y. "Sterilization Science and Technology" in Recent Innovation in Biomanufacturing, UNESCO, Bangkok, Thailand, 1996.

Montgomery, S., K. Wong, D. J. Mooney, J. L. Linderman, H. Y. Wang, M. A. Burns and H. S. Fogler. "Chemical Eningeering Fundamentals in Biological Systems - Multimedia Modules" CACHE News, 5-14, 1996.

Natarajan, M.R., J. Nye, W.M. Wu, H. Wang and M. K. Jain. “Reductive Dechlorination of PCB-Contaminated Raisin River Sediments by Anaerobic Micorbial Granules” Biotechnol. Bioeng., 55:182-190, 1997.

Natarajan, M.R., W.M. Wu, H. Wang, L. Bhatnagar and M. Jain. “Dechlorination of Spiked PCBs in Lake Sediment by Anaerobic Microbial Granules” Water Research, , 32:3013-3020, 1998.

Malakul, P., K. R. Srinivasan and H. Y. Wang. “ Metal Adsorption and Desorption Characteristics of
Surfactant-Modified Clay Complexes” Ind. Chem Res., 37:4296-4301, 1998.

Komolpis, K., P.B. Kaufman and H.Y. Wang. “Chemical Permeabilization and in-Situ Removal of Daidzein from Biologically Viabvle Soybean (Glycine max) Biotechnol. Techniques., 12:697-700, 1998.

Malakul, P., K.R. Srinivasan and H.Y. Wang. “Metal Toxicity Reduction in PAH Biodegradation Using Metal
Chelating Adsorbents” Appl. Environ. Microb., 64:4610-4613, 1998.

Wu, E., K. Komolpis and H.Y. Wang. “Chemical Extraction of Indigo Blue from Biologically Active Plants - A Feasibility study” Biotechnol. Techniques 13:567-569, 1999.

Shotipruk A., P.B. Kaufman and H.Y. Wang. “Conceptual Design of LED Based Hydroponic Photobioreactor for High Density Plant Cultivation” Biotechnol. Progress, 15(6):1058-1064, 1999.

Komolpis, K., P.B. Kaufman, P. Malakul and H.Y. Wang. “Solvent Effect on the Permeabilization of Metabolites from Biologically Viable Soybeans” Biotechnol. Progress, (in press), 2001.

Malakul, P. and H.Y. Wang. “Bioavailability of Sorbed Organic Species in Solid Adsorbents: Influence of Sorbate - Sorbent Interactions” Environ. Science and Technol., submitted for publication, 2001.