List of selected publications from PubMed

Fallahi-Sichani M, Linderman JJ. Lipid raft-mediated regulation of G-protein coupled receptor signaling by ligands which influence receptor dimerization: A computational study. PLoS ONE. 2009;4(8):e6604.

Mehta G, Lee J, Cha W, et al. Hard top soft bottom microfluidic devices for cell culture and chemical analysis. Anal Chem. 2009;81:3714-3722.

Kirschner DE, Linderman JJ. Mathematical and computational approaches can complement experimental studies of host-pathogen interactions. Cell Microbiol. 2009;11:531-539.

Linderman JJ. Modeling of G-protein-coupled receptor signaling pathways. J Biol Chem. 2009;284:5427-5431.

Brinkerhoff CJ, Traynor JR, Linderman JJ. Collision coupling, crosstalk, and compartmentalization in G-protein coupled receptor systems: can a single model explain disparate results? J Theor Biol. 2008;255:278-286.

Chang ST, Linderman JJ, Kirschner DE. Effect of multiple genetic polymorphisms on antigen presentation and susceptibility to Mycobacterium tuberculosis infection. Infect Immun. 2008;76:3221-3232.

Brinkerhoff CJ, Choi JS, Linderman JJ. Diffusion-limited reactions in G-protein activation: unexpected consequences of antagonist and agonist competition. J Theor Biol. 2008;251:561-569.

Chang ST, Linderman JJ, Kirschner DE. Effect of multiple genetic polymorphisms on antigen presentation and susceptibility to Mycobacterium tuberculosis infection. Infect Immun. 2008;76:3221-3232.

Clark MJ, Linderman JJ, Traynor JR. Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model. Mol Pharmacol. 2008;73:1538-1548.

Riggs T, Walts A, Perry N, et al. A comparison of random vs. chemotaxis-driven contacts of T cells with dendritic cells during repertoire scanning. J Theor Biol. 2008;250:732-751.

Comisar WA, Kazmers NH, Mooney DJ, Linderman JJ. Engineering RGD nanopatterned hydrogels to control preosteoblast behavior: a combined computational and experimental approach. Biomaterials. 2007;28:4409-4417.

Kinzer-Ursem TL and Linderman JJ. Both ligand- and cell-specific parameters control ligand agonism in a kinetic model of g protein-coupled receptor signaling. PLoS Comput Biol. 2007;3:e6.

Kirschner DE, Chang ST, Riggs TW, Perry N, Linderman JJ. Toward a multiscale model of antigen presentation in immunity. Immunol Rev. 2007;216:93-118.

Mehta G, Mehta K, Sud D, et al. Quantitative measurement and control of oxygen levels in microfluidic poly(dimethylsiloxane) bioreactors during cell culture. Biomed Microdevices. 2007;9:123-134.

Thwar PK, Guptaroy B, Zhang M, Gnegy ME, Burns MA, Linderman JJ. Simple transporter trafficking model for amphetamine-induced dopamine efflux. Synapse. 2007;61:500-514.

Thwar PK, Linderman JJ, Burns MA. Electrodeless direct current dielectrophoresis using reconfigurable field-shaping oil barriers. Electrophoresis. 2007;28:4572-4581.

Chang ST, Ghosh D, Kirschner DE, Linderman JJ. Peptide length-based prediction of peptide-MHC class II binding. Bioinformatics. 2006;22:2761-2767.

Comisar WA, Hsiong SX, Kong HJ, Mooney DJ, Linderman JJ. Multi-scale modeling to predict ligand presentation within RGD nanopatterned hydrogels. Biomaterials. 2006;27:2322-2329.

Kinzer-Ursem TL, Sutton KL, Waller A, Omann GM, Linderman JJ. Multiple receptor states are required to describe both kinetic binding and activation of neutrophils via N-formyl peptide receptor ligands. Cell Signal. 2006;18:1732-1747.

Mehta K and Linderman JJ. Model-based analysis and design of a microchannel reactor for tissue engineering. Biotechnol Bioeng. 2006;94:596-609.

Brinkerhoff CJ and Linderman JJ. Integrin dimerization and ligand organization: key components in integrin clustering for cell adhesion. Tissue Eng. 2005;11:865-876.

Chang PS, Axelrod D, Omann GM, Linderman JJ. G protein threshold behavior in the human neutrophil oxidant response: measurement of G proteins available for signaling in responding and nonresponding subpopulations. Cell Signal. 2005;17:605-614.

Chang ST, Linderman JJ, Kirschner DE. Multiple mechanisms allow Mycobacterium tuberculosis to continuously inhibit MHC class II-mediated antigen presentation by macrophages. Proc Natl Acad Sci U S A. 2005;102:4530-4535.

Brinkerhoff CJ, Woolf PJ, Linderman JJ. Monte Carlo simulations of receptor dynamics: insights into cell signaling. J Mol Histol. 2004;35:667-677.

Chang PS, Absood A, Linderman JJ, Omann GM. Magnetic bead isolation of neutrophil plasma membranes and quantification of membrane-associated guanine nucleotide binding proteins. Anal Biochem. 2004;325:175-184.

Waller A, Sutton KL, Kinzer-Ursem TL, et al. Receptor binding kinetics and cellular responses of six N-formyl peptide agonists in human neutrophils. Biochemistry. 2004;43:8204-8216.

Woolf PJ and Linderman JJ. An algebra of dimerization and its implications for G-protein coupled receptor signaling. J Theor Biol. 2004;229:157-168.

Keil ML, Solomon NL, Lodhi IJ, et al. Priming-induced localization of G(ialpha2) in high density membrane microdomains. Biochem Biophys Res Commun. 2003;301:862-872.

Shim J, Bersano-Begey TF, Zhu X, Tkaczyk AH, Linderman JJ, Takayama S. Micro- and nanotechnologies for studying cellular function. Curr Top Med Chem. 2003;3:687-703.

Woolf PJ and Linderman JJ. Self organization of membrane proteins via dimerization. Biophys Chem. 2003;104:217-227.

Woolf PJ and Linderman JJ. Untangling ligand induced activation and desensitization of G-protein-coupled receptors. Biophys J. 2003;84:3-13.

Zhong H, Wade SM, Woolf PJ, Linderman JJ, Traynor JR, Neubig RR. A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protien-mediated kinetic scaffolding. J Biol Chem. 2003;278:7278-7284.

Cunningham JJ, Linderman JJ, Mooney DJ. Externally applied cyclic strain regulates localization of focal contact components in cultured smooth muscle cells. Ann Biomed Eng. 2002;30:927-935.

Cunningham JJ, Nikolovski J, Linderman JJ, Mooney DJ. Quantification of fibronectin adsorption to silicone-rubber cell culture substrates. BioTechniques. 2002;32:876, 878, 880 passim.

Waller A, Pipkorn D, Sutton KL, Linderman JJ, Omann GM. Validation of flow cytometric competitive binding protocols and characterization of fluorescently labeled ligands. Cytometry. 2001;45:102-114.

Woolf PJ, Kenakin TP, Linderman JJ. Uncovering biases in high throughput screens of G-protein coupled receptors. J Theor Biol. 2001;208:403-418.

Shea LD, Neubig RR, Linderman JJ. Timing is everything the role of kinetics in G protein activation. Life Sci. 2000;68:647-658.

Riccobene TA, Omann GM, Linderman JJ. Modeling activation and desensitization of G-protein coupled receptors provides insight into ligand efficacy. J Theor Biol. 1999;200:207-222.