Multi-Scale Modeling of Biological Systems, Receptor Dynamics, Mathematical Modeling of Biological Processes, Cell and Tissue Engineering, Regenerative Medicine

My current study is to apply mathematical modeling for identifying the mechanisms that determine TNF availability for the purpose of understanding how granulomas form in response to tuberculosis (TB) infection as well as how treatment with anti-TNF-therapies leads to TB reactivation. I am focusing on TNF receptor dynamics.

 

Fallahi-Sichani M, Linderman JJ. Lipid raft-mediated regulation of G-protein coupled receptor signaling by ligands which influence receptor dimerization: A computational study. PLoS ONE 2009; 4(8): e6604.

Fallahi-Sichani M, Soleimani M, Najafi SM, Kiani J, Arefian E, Atashi A. In vitro differentiation of cord blood unrestricted somatic stem cells expressing dopamine-associated genes into neuron-like cells. Cell Biol Int. 2007; 31:299-303.

Mohammadi Y, Soleimani M, Fallahi-Sichani M, Gazme A, Haddadi-Asl V, Arefian E, Kiani J, Moradi R, Atashi A, Ahmadbeigi N. Nanofibrous poly(epsilon-caprolactone)/poly(vinyl alcohol)/chitosan hybrid scaffolds for bone tissue engineering using mesenchymal stem cells. Int J Artif Organs. 2007; 30:204-11.