Lahann Lab

A. M. Ross, H. Nandivada, A. L. Ryan, J. Lahann, "Synthetic Substrates for Long-Term Stem Cell Culture", Polymer (2012).

L. G. Villa-Diaz, S. E. Brown, Y. Liu, A. M. Ross, J. Lahann, J. M. Parent, P. H. Krebsbach, "Derivation of Mesenchymal Stem Cells from Human Induced Pluripotent Stem Cells Cultured on Synthetic Substrates", Stem Cells (2012).

X. Deng*, T. W. Eyster*, Y. Elkasabi, J. Lahann, "Bio-Orthogonal Polymer Coatings for Co-Presentation of Biomolecules", Macromolecular Rapid Communications (2012).

L. G. Villa-Diaz*, H. Nandivada*, J. Ding, N. C. Nogueira-de-Souza, P. H. Krebsbach, K. Sue O'Shea, J. Lahann and G. D. Smith "Synthetic polymer coatings for long-term growth of human embryonic stem cells", Nature Biotechnology (2010) 28(6), 581-583. [*co-first-authors]

H. Nandivada, A. M. Ross, J. Lahann, "Stimuli responsive monolayers for biotechnology", Progress in Polymer Science (2010) 35(1-2), 141-154.

D. W. Lim, S. Hwang, O. Uzun, F. Stellacci, J. Lahann, "Compartmentalization of Gold Nanocrystals in Polymer Microparticles Using Electrohydrodynamic Co-jetting", Macromolecular Rapid Communications (2010) 31(2), 176-182.

A. Kazemi, J. Lahann, M. Madani, N. S. Sanjani, A. H. Kaviar, "Preparation of Core-Shell and Hollow Fibers Using Layer by Layer (LbL) Self-Assembly of Polyelectrolytes on Electrospun Submicrometer-Scale Silica Fibers", Polymer Science Series B (2010) 52(9-10), 571-574.

S. Bhaskar, K. M. Pollock, M. Yoshida, J. Lahann, "Towards Designer Microparticles: Simultaneous Control of Anisotropy, Shape, and Size", Small (2010) 6(3), 404-411.

M. Yoshida, K-H. Roh, S. Mandal, S. Bhaskar, D. W. Lim, H. Nandivada, X. Deng, J. Lahann, "Structurally Controlled Bio-hybrid Materials Based on Unidirectional Association of Anisotropic Microparticles with Human Endothelial Cells", Advanced Materials (2009) 21(48), 4920-4925.

S. Mandal, S. Bhaskar, J. Lahann, "Micropatterned Fiber Scaffolds for Spatially-Controlled Cell Adhesion", Macromolecular Rapid Communications (2009) 131(19), 6650-6651.

Y. Elkasabi, H. Nandivada, H-Y Chen, S. Bhaskar, J. D'Arcy, L. Bondarenko, J. Lahann, "Partially Fluorinated Poly-p-xylylenes Synthesized by CVD Polymerization", Chemical Vapor deposition (2009) 15(4-6), 142-149.

A. Sun and J. Lahann, "Dynamically Switchable Biointerfaces" Soft Matter (2009) 5(8), 1555-1561.

S. Bhaskar, J. Hitt, S-W. L. Chang, J. Lahann, "Multicompartmental Microcylinders" Angew Chemie Int Ed 48(25), 4589-4593.

S. Bhaskar, J. Lahann, "Microstructured Materials based on Multicompartmental Fibers", JACS 131(19), 6650-6651.

S. Mitragotri and J. Lahann, "Physical approaches to biomaterial design", Nature Materials (2009) 8, 15-23.

Y. Elkasabi, J. Lahann, "Vapor-based polymer gradients", Macromolecular Rapid Communications (2009) 30, 1, 57-63.

A. Kazemi, J. Lahann, "Environmentallly responsive core/shell particles via electrohydrodynamic co-jetting of fully miscible polymer solutions", Small (2008) 4(10), 1756-1762.

S. Bhaskar, K-H. Roh, X.W. Jiang, G.L. Baker, J. Lahann, "Spatioselective modification of bicompartmental polymer particles and fibers via Huisgen 1,3-dipolar cycloaddition", Macromolecular rapid communications (2008) 29(20), 1655-1660.

D.K. Peng, A.A. Ahmadi, J. Lahann, "A synthetic surface that undergoes spatiotemporal remodeling", Nano Letters (2008) 8(10), 3336-3340.

H.Y. Chen, J.H Lai, X.W. Jiang, J. Lahann, "Substrate-selective chemical vapor deposition of reactive polymer coatings", Advanced Materials (2008) 20(18), 3474.

Metal-mediated inhibition of CVD polymerization of functionalized [2.2]paracyclophane with a wide range of functional groups is investigated and selective deposition is established for poly(4-vinyl-p-xylylene-co-p-xylylene).

Y. Elkasabi, M. Yoshida, H. Nandivada, H-Y. Chen, J. Lahann, "Towards multipotent coatings: Chemical vapor deposition and biofunctionalization of carbonyl-substituted copolymers", Macromolecular rapid communications (2008) 29(11), 855-870.

We report the development of multifunctional polymer coatings made by chemical vapor deposition (CVD) copolymerization.

M. Yoshida, J. Lahann, "Smart Nanomaterials", ACS Nano (2008) 2(6), 1101-1107. [Perspective]

“Smart” materials are materials that undergo dynamic and reversible changes in specific properties in response to certain environmental stimuli. In this perspective, challenges in the field of "smart" materials are highlighted.

J. Lahann, "Environmental nanotechnology - Nanomaterials clean up", Nature Nanotechnology (2008) 3(6), 320-321.

Hsien-Yeh Chen, Arthur McClelland, Zhan Chen, Joerg Lahann, "Solventless Adhesive Bonding Using Reactive Polymer Coatings", Analytical Chemistry (2008) 80(11), 4119-4124.

A novel solventless adhesive bonding (SAB) process is reported, which is applicable to a wide range of materials including, but not limited to, poly(dimethylsiloxane) (PDMS). The bonding is achieved through reactions between two complementary polymer coatings, poly(4-aminomethyl- p-xylylene- co- p-xylylene) and poly(4-formyl- p-xylylene- co- p-xylylene), which are prepared by chemical vapor deposition (CVD) polymerization of the corresponding [2.2]paracyclophanes and can be deposited on complementary microfluidic units to be bonded. These CVD-based polymer films form well-adherent coatings on a range of different substrate materials including polymers, glass, silicon, metals, or paper and can be stored for extended periods prior to bonding without losing their bonding capability.

X. Jiang, H.-Y. Chen, G. Galvan, M. Yoshida, J. Lahann, "Vapor-based initiator coatings for atom transfer radical polymerization", Advanced Functional Materials (2008) 18(1), 27-35.

Chemical vapor deposition of [2.2]paracyclophane-4-methyl 2-bromoisobutyrate was prepared on a wide range of materials as initiator coating. Surface initiated atom transfer radical polymerization of a oligo(ethylene glycol) methyl ether methacrylate was demonstrated on these surfaces as model example for the regulations of protein adsorption and cell adhesion.

S. Thevenet, H-Y. Chen, J. Lahann, F. Stellaci, "A generic approach towards nanostructured surfaces based on supramolecular nanostamping on reactive polymer coatings", Advanced Materials (2007) 19(24), 4333-4337.

Various surfaces can successfully be coated with reactive polymer coatings and then patterned with DNA features using supramocular nanostamping (SuNS). Surfaces as different as silicon, quartz, polystyrene, PMMA and PDMS have been patterned using the same protocol. In addition to the previously demonstrated high resolution and high information transfer of SuNS this approach makes it a substrate-independent method.

K-H. Roh, M. Yoshida, J. Lahann, "Compartmentalized, multiphasic nanocolloids with potential applications in drug delivery and biomedical imaging", Materialwissenschaft und werkstofftechnik (2007) 38(12), 1008-1011.

Nanoparticles are excellent candidates for drug delivery or biomedical imaging, because they often exhibit superb tuneability of critical properties, such as size, surface characteristics, degradation rate, and therefore drug release rates. We have recently developed a route towards fabrication of sub-micron particles that relies on electrohydrodynamic co-jetting. In this process, fluid manipulation in an electrical field is used to fabricate large quantities of multi-compartment particles, where individual compartments can be independently loaded with different drugs or selectively surface-modified. In this contribution, aspects of multifunctional particles for biomedical applications are reviewed and a specific focus is given to recent progress with compartmentalized, multiphasic nanocolloids in our laboratory.

H-Y. Chen, J. Lahann, "Vapor-assisted micropatterning in replica structures: A solventless approach towards topologically and chemically designable surfaces", Advanced Materials (2007) 19(22), 3801-3808.

Vapor-assisted micropatterning in replica structures (VAMPIR) provides a simple method for fabricating both, chemically and topologically designable surfaces based on chemical vapor deposition polymerization. The images show surface microstructures containing fluorescence-labeled proteins or quantum dots.

H. Nandivada, X. Jiang, J. Lahann, "Click Chemistry: Versatility and control in the hands of materials scientists", Advanced Materials (2007) 19, 2197-2208.

H.-Y. Chen, J.-M. Rouillard, E. Gulari, J. Lahann, "Colloids with High-Definition Surface Structures", PNAS (2007) 104 (27), 11173-11178.

A highthroughput projection lithography technique was applied on micro-spheres which were modified previously by photodefinable CVD polymer. This method can yield surface-structured colloidal particles at a rate of 10⁷ to 10⁸ particles per operator per day. Equipped with spatially defined binding pockets, microstructured colloids can engage in programmable interactions, which can lead to directed self-assembly. The ability to create a wide range of colloids with both simple and complex surface patterns may contribute to the genesis of previously unknown colloidal structures and may have important technological implications in a range of different applications, including photonic and phononic materials or chemical sensors.

M. Yoshida, K.H. Roh, J. Lahann, "Short-term biocompatibility of biphasic nanocolloids with potential use as anisotropic imaging probes", Biomaterials (2007) 28, 15, 2446-2456.

K.H. Roh, M. Yoshida, J. Lahann, "Water-stable Biphasic Nanocolloids with Potential Use as Anisotropic Imaging Probes", Langmuir (2007) 23, 10, 5683-5688.

Artistic rendering of water- stable biphasic nanocolloids, which are prepared by electrified co-jetting of two jetting solutions through side-by-side capillaries and subsequent thermal imidization reaction. Two aqueous polymer solutions containing different biomolecules were employed as jetting solutions. Originally, water-soluble particles become water-insoluble by thermal imidization reaction, and the colloid suspension showed stability over multiple weeks in an aqueous environment.

D.K. Peng. S.T. Yu, D.J. Alberts, J. Lahann, "Switching the Electrochemical Impedance of Low-Density Self-Assembled Monolayers", Langmuir (2007) 23, 1, 297-304.

K.-H. Roh, J. Lahann, "Anisotropic encapsulation of supermagentic nanocrystals in polymeric biphasic nanocolloids", Polymer Preprints (2007) 48, 209-210

L. Bondarenko, J.W. Kampf, J. Lahann, "The Synthesis of Brominated Tetrafluoro[2.2]paracyclophanes", European Journal of Organic Chemistry (2006) 5499-5504.

M. Yoshida, R. Langer, A. Lendlein, and J. Lahann, "From advanced biomedical coatings to intelligent biomaterials", Polymer Reviews (2006) 46, 347-375.

J. Lahann, "Vapor-Based Polymer Coatings For Potential Biomedical Applications", Polymer International (2006) 55 (12), 1361-1370. 

Y. Elkasabi, H.Y. Chen, J. Lahann, "Multi-potent polymer coatings based on chemical vapor deposition co-polymerization", Advanced Materials (2006) 18, 1521-1526.

Using chemical vapor deposition co-polymerization, we have developed a simple strategy towards multi-functional surfaces presenting two different biological ligands in controllable ratios. These modularly designable polymer coatings are applicable to a wide range of biomedical devices including microanalytical or diagnostic systems.

K.H. Roh, D.C. Martin, J. Lahann, "Triphasic Nanocolloids", Journal of the American Chemical Society (2006) 128, 21, 6796-6797.

H. Nandivada, H.Y. Chen, L. Bondarenko, J. Lahann, "Reactive polymer coatings that "click"", Angewandte Chemie International Edition (2006) 45, 20, 3360-3363.

Vapor-based alkyne-containing polymer coatings have showed remarkable reactivity towards azides via the chemoselective Huisgen’s 1,3-dipolar cycloaddition. As a flexible bioconjugation platform, this regioselective immobilization strategy could be applicable in the design of biofunctional surfaces for diagnostics (e.g. microarrays), biosensors, and biomedical device coatings. 

H.Y. Chen, Y. Elkasabi, J. Lahann, "Surface modification of confined microgeometries via vapor-deposited polymer coatings", Journal of the American Chemical Society (2006) 128, 1, 374-80.

Chemical vapor deposition polymerization within confined geometries.

Y. Wang, Z. Tang, P. Podsiadlo, Y. Elkasabi, J. Lahann, N.A. Kotov, "Mirror-Like Photoconductive Layer-by-Layer Thin Films of Te Nanowires: The Fusion of Semiconductor, Metal, and Insulator Properties", Advanced Materials (2006) 18, 518-522.

Corresponding author: Nicholas A. Kotov.

J.M. Wu, Y. Chung, K.J. Belford, G.D. Smith, S. Takayama, J. Lahann. "A Surface-Modified Sperm Sorting Device with Long-Term Stability", Biomedical Microdevices (2006) 8, 99-107.

K.H. Roh, D.C. Martin, J. Lahann, "Biphasic Janus particles with nanoscale anisotropy", Nature Materials (2005) 4, 759-763.

Anisotropic material distribution can be induced at the nanometer scale by the use of electrified jetting. Side-by-side dual capillaries were employed to expose two distinct parallel polymer solutions to an electrical field simultaneously. The individual phases of the resulting polymer-based Janus particles can be independently loaded with biomolecules or selectively modified with reactive ligands.

H. Nandivada, H. Y Chen, J. Lahann, "Vapor-Based Synthesis of Poly[(4-formyl-p-xylylene)-co-(p-xylylene)] and Its Use for Biomimetic Surface Modifications", Macromolecular Rapid Communications (2005) 26, 1794-1799.

The synthesis of a reactive polymer, poly(4-formyl-p-xylylene-co-p-xylylene), via chemical vapor deposition (CVD) polymerization is reported. Moreover, usefulness of these polymer coatings for biomimetic surface modifications is demonstrated.

H.Y. Chen, J. Lahann, "Fabrication of Discontinuous Surface Patterns within Microfluidic Channels Using Photodefinable Vapor-Based Polymer Coatings", Analytical Chemistry (2005) 77, 6909-6914.

Spatially controlled protein adsorption via photopatterning of reactive coatings deposited within microchannels.

J. Lahann, R. Langer, "Smart Materials with Dynamically Controllable Surfaces", MRS Bulletin (2005) 30, 3, 185-188.

H.Y. Chen, J. Lahann, "Preparation of Non-Fouling Coatings Made by Chemical Vapor Deposition Polymerization", Polymer Preprints (2005) 46(2), 1280-1281

J. Lahann, "Bio-Functional Polymer Coatings Based on Chemical Vapor Deposition", PMSE Preprints (2005) 92, 39-40.

K.Y. Suh, R. Langer, J. Lahann, "A novel photodefinable reactive polymer coating and its use for microfabrication of hydrogel elements", Advanced Materials (2004) 16, 16, 1401-1405.

K. Schürmann, J. Lahann, J. Meyer, H. Klosterhalfen, D. Vorwerk, D. Klee, R.W. Günther, "Biologic Response to Polymer-Coated Stents Examined in a Iliac Artery Sheep Model", Radiology (2004) 230, 1, 151-162.