3D Scaffolds for Tissue
Engineering and Drug Discovery
Experimental data from a variety of groups and in a
variety of tissues point to the fact that 3D
organization of cells is critical for their proper
functioning in ex-vivo conditions. Recently we
introduced a new type of 3D scaffolds that makes
possible (1) standardization of cell development
conditions; (2) highly reproducible and ordered 3D
architecture, (3) easy interrogation by spectroscopic
means, and (4) simplicity of surface functionalization
with a variety of bioactive molecules. They are made on
the basis of inverted colloidal crystals made from
either silicate or hydrogel. The key problem of the
hydrogel scaffold, such as poor adhesion of cells, was
successfully solved by using layer-by-layer modification
of the scaffold surface.
Projects
▪ Inverted
Colloidal Crystals as Three Dimensional
Microenvironments for Cellular Co-Cultures /
Jungwoo Lee
▪ Inverted
Colloidal Crystal 3-D Scaffolds for Liver Tissue Analog
for Toxicology Screening and 3D Drug Testing /
Jungwoo Lee
and
Meghan Cuddihy
▪ Multi-scale
Scaffold Engineering of Bone Tissue Scaffolds /
Meghan Cuddihy
▪ Standardized
3D Cell Culture in Well0Plate Platform for Drug
Screening /
Joong Bahng
▪ 3D Scaffolds
with Inverted Colloidal Crystal Geometry from Expandable
Cationic Hydrogel for Well-Plate Format /
Joong Bahng
▪
3D Scaffolds for
Neural Tissue Engineering and for Rapid Expansion and
Directed Differentiation of Neural Stem Cells /
Edward
Jan
Selected Publications
▪
Lee J, Shanbhag S, Kotov NA Inverted colloidal crystals as three-dimensional
microenvironments for cellular co-cultures JOURNAL OF
MATERIALS CHEMISTRY 16 (35): 3558-3564 2006
▪
Liu YF, Wang SP, Lee JW, et
al.
A floating self-assembly route to colloidal crystal
templates for 3D cell scaffolds CHEMISTRY OF MATERIALS
17 (20): 4918-4924 OCT 4 2005
▪
Shanbhag S, Wang SP, Kotov
NA Cell distribution profiles in three-dimensional
scaffolds with inverted-colloidal-crystal geometry:
Modeling and experimental investigations SMALL 1 (12):
1208-1214 DEC 2005
▪
Zhang YJ, Wang SP, Eghtedari
M, et al.
Inverted-colloidal-crystal hydrogel matrices
as three-dimensional cell scaffolds ADVANCED FUNCTIONAL
MATERIALS 15 (5): 725-731 MAY 2005
▪
Kotov NA, Liu YF, Wang
SP, et al.
Inverted colloidal crystals as
three-dimensional cell scaffolds LANGMUIR 20 (19):
7887-7892 SEP 14 2004
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